University of Texas Southwestern Medical Center/Children’s Medical Center

5323 Harry Hines Boulevard, Department of Pediatrics
Dallas
TX
75390-9063
USA
Contact Person: Darlene Washington
Phone: (214) 648-3720
Fax: (214) 648-2961

TRAINING PROGRAM DIRECTOR/CHIEF OF INFECTIOUS DISEASES: Jeffrey S. Kahn., MD, PhD
RESEARCH INTERESTS: Epidemiology and clinical features of newly emerging  human pathogens. Molecular characterization of respiratory syncytial virus.  

TRAINING PROGRAM CO-DIRECTOR: Michael Serbert, MD
RESEARCH INTEREST: Pathogenesis and genetics of Streptococcus pneumonia; Health care epidemiology and infection prevention and control

ASSOCIATES/DIVISION MEMBERS:

  • George McCracken, MD
    Research Interest:  Pediatric infectious diseases, meningitis, respiratory infectious diseases. The epidemiology of invasive pneumococcal disease in Dallas and the effectiveness of daptomycin in children with serious MRSA infections
     
  • Jane Siegel, MD
    Research Interest: Community-acquired MRSA infections, healthcare associated infections; Infections in immunocompromised hosts
     
  • Michelle Gill, MD, PhD
    Research Interest: Immunobiology of human dendritic cells and their role in the pathogenesis of clinical disease processes
     
  • Jeffrey McKinney, MD, PhD
    Research Interest: Graduate medical education, development and implementation of educational tools and resources
     
  • Amanda Evans, MD
    Research Interest: Biology and pathogenesis of Moraxella catarrhalis
     
  • Dawn Wetzel, MD, PhD
    Research Interest: Molecular biology and pathogenesis of Leishmania
     
  • Michelle Hsiang, MD
    Research Interest: Epidemiology of malaria, strategies for elimination and eradication; global health

TITLE(S) OF SOME RECENT FELLOWS' PUBLISHED PAPERS OR RESEARCH PROJECTS:

  1.  Gene Expression Analysis of Children with Acute Hematogenous Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus: Correlation with Clinical Severity of Illness. Gaviria-Agudelo C, Carter K, Tareen N, Pascual V, Copley LA. PLoS One. 2014 Jul 30;9(7):e103523. doi: 10.1371/journal.pone.0103523. eCollection 2014.
  2. Antimicrobial stewardship in the NICU. Cantey JB, Patel SJ. Infect Dis Clin North Am. 2014 Jun;28(2):247-61. doi: 10.1016/j.idc.2014.01.005. PMID: 24857391 [PubMed - in process]
  3. Rac MW, Bryant SN, McIntire DD, Cantey JB, Twickler DM, Wendel GD Jr, Sheffield JS. Progression of ultrasound findings of fetal syphilis after maternal treatment. Am J Obstet Gynecol. 2014 Jun 4. pii: S0002-9378(14)00563-8. doi: 10.1016/j.ajog.2014.05.049. [Epub ahead of print] PubMed PMID: 24907700.
  4. Oliveira CR, Morriss MC, Mistrot JG, Cantey JB, Doern CD, Sánchez PJ. Brain magnetic resonance imaging of infants with bacterial meningitis. J Pediatr. 2014 Jul;165(1):134-9. doi: 10.1016/j.jpeds.2014.02.061. Epub 2014 Apr 13. PubMed PMID: 24726712.
  5. Cantey JB, Sánchez PJ, Tran J, Chung W, Siegel JD. Pertussis: a persistentcause of morbidity and mortality in young infants. J Pediatr. 2014. Jun;164(6):1489-92.e1. doi: 10.1016/j.jpeds.2014.01.023. Epub 2014 Feb 22. PubMed PMID: 24565424.
  6. Cantey JB, Sreeramoju P, Jaleel M, Treviño S, Gander R, Hynan LS, Hill J,Brown C, Chung W, Siegel JD, Sánchez PJ. Prompt control of an outbreak caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit. J Pediatr. 2013 Sep;163(3):672-9.e1-3. doi:10.1016/j.jpeds.2013.03.001. Epub 2013 Apr 10. PubMed PMID: 23582136.
  7. Burnaevskiy N, Fox TG, Plymire DA, Ertelt JM, Weigele BA, Selyunin AS, Way SS, Patrie SM, Alto NM. Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Nature. 2013 Apr 4;496(7443):106-9. doi: 10.1038/nature12004. Epub 2013 Mar 27. PubMed PMID: 23535599; PubMed Central PMCID: PMC3722872.
  8. Lopez-Medina E, Ardura MI, Siegel JD, Brock E, Sánchez PJ. 2009 influenza A in infants hospitalized at younger than 6 months. J Pediatr. 2012 Apr;160(4):626-631.e1. doi: 10.1016/j.jpeds.2011.09.060. Epub 2011 Nov 17. PubMed PMID: 22099687.
  9. Lopez-Medina E, Neubauer MM, Pier GB, Koh AY. RNA isolation of Pseudomonas aeruginosa colonizing the murine gastrointestinal tract. J Vis Exp. 2011 Sep 28;(55). pii: 3293. doi: 10.3791/3293. PubMed PMID: 21989513; PubMed Central PMCID: PMC3230207.
  10. Mejias A, Dimo B, Suarez NM, Garcia C, Suarez-Arrabal MC, Jartti T, Blankenship D, Jordan-Villegas A, Ardura MI, Xu Z, Banchereau J, Chaussabel D, Ramilo O. Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med. 2013 Nov;10(11):e1001549. doi: 10.1371/journal.pmed.1001549. Epub 2013 Nov 12. PubMed PMID: 24265599; PubMed Central PMCID: PMC3825655
  11. Chang ML, Jordan-Villegas A, Evans A, Bhore R, Brock E, Mejias A, Siegel JD. Respiratory viruses identified in an urban children's hospital emergency department during the 2009 influenza A(H1N1) pandemic. Pediatr Emerg Care. 2012 Oct;28(10):990-7. doi: 10.1097/PEC.0b013e31826ca980. PubMed PMID: 23023466.
  12. Jordan-Villegas A, Chang ML, Ramilo O, Mejías A. Concomitant respiratory viral infections in children with Kawasaki disease. Pediatr Infect Dis J. 2010 Aug;29(8):770-2. doi: 10.1097/INF.0b013e3181dba70b. PubMed PMID: 20354462; PubMed Central PMCID: PMC2927322
  13. Wang W, Joslin SN, Pybus C, Evans AS, Lichaa F, Brautigam CA, Hansen EJ. Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model. Infect Immun. 2014 Jun;82(6):2287-99. doi: 10.1128/IAI.01745-14. Epub 2014 Mar 18. PubMed PMID: 24643539; PubMed Central PMCID: PMC4019179.
  14. Evans AS, Pybus C, Hansen EJ. Development of a LacZ-based transcriptional reporter system for use with Moraxella catarrhalis. Plasmid. 2013 Mar;69(2):180-5. doi: 10.1016/j.plasmid.2012.11.003. Epub 2012 Dec 4. PubMed PMID: 23219721; PubMed Central PMCID: PMC3570615.

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

  1. Alejandro Jordan Villegas. 2010 Pediatric Infectious Diseases Society Fellowship Award in Viral Respiratory Infectious Diseases for the project "Immunopathogenesis of RSV and Streptococcus Pneumoniae Pneumonia" at the Pediatric Academic Societies' 2009 Annual Meeting (SPR-APS). May, 2009, Baltimore, Maryland.
  2. Amanda Evans 2010-2012. Ruth L. Kirschstein-National Research Service Award (T32 AI070116)
  3. Joseph Cantey. 20111 Gerber Foundation. Use and Misuse of Antibiotic Therapy in the Neonatal Intensive Care Unit

MAJOR FEATURES OF TRAINING PROGRAM: 
The purposes of the training program are to provide a background in laboratory techniques of classical microbiology, immunology, epidemiology, and molecular biology, to provide experience in the application of the scientific method to clinical and laboratory research, to develop competence in diagnosis and management of infectious diseases and to provide expertise in infection control. Clinical training is in the form of consultations (inpatient and outpatient), rounds and conferences. The clinical material available at Children's Medical Center (CMC) and Parkland Memorial Hospital is extensive. There are more than 300,000 outpatient visits, >15,000 pediatric admissions, and 17,000 newborns per year. The division has established collaborative research programs with the clinical and basic science investigators in many departments in The University of Texas Southwestern Medical Center and beyond including the Dallas County Department of Health and Human Service. The principal goals of these collaborative projects are to delineate the molecular and or epidemiological basis for the pathogenesis of certain infectious diseases in pediatrics.

AFFILIATED HOSPITALS:

  • Children's Medical Center
    Number of PediatricBeds: 485
     
  • Parkland Memorial Hospital
    Number of Pediatric Beds: 100 (NICU beds)

FELLOWS ACCEPTED EACH YEAR:  2-3

TRAINING FOR MD; DO; MD, PhD: YES

FUNDING IS ENSURED FOR ALL 3 YEARS: YES

VISAS ACCEPTED: J1 only

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? NO

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

Program provides training in diagnostic microbiology using laboratories on site:

  • Microbiology laboratory: YES
  • Clinical virus isolation laboratory: YES
  • Molecular diagnostics: YES
  • Other: Microbial genomics

Program provides training in infection control and hospital epidemiology as:

  • Didactic lectures: YES
  • Hands on experience: YES
  • Infection Control Meetings/Membership: YES

Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:

  • Bacteriology/bacterial infections: YES
  • Epidemiology and statistics: YES
  • Infection control/hospital epidemiology: YES
  • Immunizations/Public health: YES
  • Mycology/fungal infections: YES
  • Parasitology/parasitic diseases: YES
  • Virology/viral diseases: YES
  • Antimicrobial agents: YES

Research opportunities in the section’s program could be describes as:

  • Basic (bench): YES
  • Molecular: YES
  • Community: YES
  • Epidemiologic: YES
  • Clinical: YES
  • International/Public Health: YES
  • Health Services: YES
  • HIV, Basic: YES
  • HIV, Clinical: YES
  • ACTG Site: NO

Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: YES

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES

Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES

Program provides substantial clinical experiences for trainees in special areas/hosts:

  • HIV: YES
  • Bone marrow transplantation: YES
  • Solid organ/transplantation: YES
  • Travelers/adoptees: YES
  • Adults: YES
  • Congenital immune deficiencies: YES

Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES

Program has an NIH-sponsored training grant: NO

The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: YES

Average number of new outpatient consultations per month: 25

Average number of established outpatient follow-up visits per month: 15

Average number of new inpatient consultations per month: 75

Number of trainees completing program in the last 5 years: 15