Children's Hospital of Pittsburgh of UPMC

4401 Penn Avenue, AOB Suite 2300
Pittsburgh
PA
15224
USA
Phone: (412) 692-7438
Fax: (412) 692-7016

TRAINING PROGRAM DIRECTOR
Philana Ling Lin, MD, MSc

CHIEF OF INFECTIOUS DISEASES
John V. Williams, MD

ASSOCIATES/DIVISION MEMBERS:

  • Philana Ling Lin, MD, MSc
  • John V. Williams, MD
  • Brian Campfield, MD
  • Michael Green, MD, MPH
  • Anita McElroy, MD, PhD
  • Marian G. Michaels, MD, MPH
  • Andrew Nowalk, MD, PhD 

RESEARCH INTEREST

Philana Ling Lin, MD, MSc
Tuberculosis; immunity; pneumococcal conjugate vaccine

John V. Williams, MD
Mechanisms by which HMPV and other respiratory viruses lead to impaired pulmonary CD8+ cells; candidate vaccines and therapeutic and monoclonal antibodies against HMPV; high through-put screening for small molecule inhibitors of HMPV; HMPV inhibition of type I interferon responses; Integrin-mediated entry of HMPV; Human T cell responses to HMPV

Brian Campfield, MD
Host-pathogen interactions in the lung; The role of follistatin-like protein 1 in lung inflammation.

Michael Green, MD, MPH
Infections in children; undergoing solid organ transplantation; Infections in children undergoing stem cell transplantation; EBV and Post-transplant lymphoproliferative disorders; Antibiotic resistance; Antimicrobial stewardship

Anita McElroy, MD, PhD
Mouse adaptive responses to RVFV vaccination; Immune correlates of protection for RVFV

Marian G. Michaels, MD, MPH
Congenital cytomegalovirus infection; lung and heart-lung, transplant infectious disease; monitoring and reporting of infectious complications in immunosuppression trials in recipients of organ transplantation; infection control

Andrew Nowalk, MD, PhD
Lyme disease; EBV in transplantation; probiotics; infections in short gut syndrome and intestinal failure; proteomics


TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:

Podd BS, Simon DW, Lopez S, Nowalk A, Aneja R, Carcillo JA. Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure. Pediatr Clin North Am. 2017 Oct;64(5):1071-1088. doi: 10.1016/j.pcl.2017.06.007. Epub 2017 Aug 18. Review.

Yamada M, Nguyen C, Fadakar P, Ganoza A, Humar A, Shapiro R, Michaels MG, Green M. Epidemiology and outcome of chronic high Epstein-Barr viral load carriage in pediatric kidney transplant recipients. Pediatr Transplant. 2018 Feb 6. doi: 10.1111/petr.13147. [Epub ahead of print]

Yamada M, Nowalk AJ. Two sides of the Epstein-Barr virus (EBV) coin: Long-term control of EBV after liver transplantation? Pediatr Transplant. 2017 Aug;21(5). doi: 10.1111/petr.12943. Epub 2017 May 22.

Horner K, Yamada M, Zuccoli G, Rosenberg S, Greene S, Vellody K, Zuckerbraun NS. A 34-Day-Old With Fever, Cerebrospinal Fluid Pleocytosis, and Staphylococcus aureus Bacteremia. Pediatrics. 2016 Jan;137(1). doi: 10.1542/peds.2015-1406. Epub 2015 Dec 7.

Kelley J, Tristram D, Yamada M, Grose C. Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella. Pediatr Infect Dis J. 2015 Sep;34(9):1027-9. doi: 10.1097/INF.0000000000000737.

Robinson KM, Lee B, Scheller EV, Mandalapu S, Enelow RI, Kolls JK, Alcorn JF. The role of IL-27 in susceptibility to post-influenza Staphylococcus aureus pneumonia. Respir Res. Respir Res. 2015 Feb 5;16(1):10. doi: 10.1186/s12931-015-0168-8.

Robinson KM, McHugh KJ, Mandalapu S, Clay ME, Lee B, Scheller EV, et al. Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production. J Infect Dis. 2013 Oct 14.

Upadhyayula S. Question 2 * is there a role for MRI as an adjunct for diagnosing bacterial meningitis? Arch Dis Child. 2013 May;98(5):388-90. doi: 10.1136/archdischild-2013-303858. Review

Upadhyayula S, Kambalapalli M, Asmar BI. Staphylococcus epidermidis Urinary Tract Infection in an Infant. Case Rep Infect Dis. 2012;2012:983153. doi: 10.1155/2012/983153. Epub 2012 Aug 9.

Conti HR, Huppler AR, Whibley N, Gaffen SL. Curr Protoc Immunol. 2014 Apr 2;105:19.6.1-19.6.17. doi: 10.1002/0471142735.im1906s105.

Bishu S, Hernández-Santos N, Simpson-Abelson MR, Huppler AR, Conti HR, Ghilardi N, Mamo AJ, Gaffen SL. The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. Infect Immun. 2014 Mar;82(3):1173-80. doi: 10.1128/IAI.01335-13. Epub 2013 Dec 30.

Hernández-Santos N, Huppler AR, Peterson AC, Khader SA, McKenna KC, Gaffen SL. Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections. Mucosal Immunol. 2013 Sep;6(5):900-10. doi: 10.1038/mi.2012.128. Epub 2012 Dec 19.

Huppler AR, Bishu S, Gaffen SL. Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. Arthritis Res Ther. 2012 Jul 23;14(4):217. doi: 10.1186/ar3893.

Campfield BT, Nolder CL, Davis A, Hirsch R, Nowalk AJ. The DBA/1 Strain is a Novel Mouse Model for Experimental Borrelia burgdorferi infection. Clin Vaccine Immunol. 2012 Aug 1.

Campfield BT, Nolder CL, Marinov A, Bushnell D, Davis A, Spychala C, Hirsch R, Nowalk AJ. Follistatin-like protein 1 is a critical mediator of experimental Lyme arthritis and the humoral response to Borrelia burgdorferi infection. Microb Pathog. 2014 Aug;73:70-9. doi: 10.1016/j.micpath.2014.04.005. Epub 2014 Apr 24.

Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R. Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells. Ann Rheum Dis. 2014 Mar 21. doi: 10.1136/annrheumdis-2013-204822.

Patrick S, Davis M, Sedman A, Meddings J, Hieber S, Lee G, Stillwell T, Chenoweth C, Espinosa C, Schukacher R. Accuracy of Hospital Administrative Data in Reporting Central-Line Associated Bloodstream Infections in Newborns. Pediatrics 2013;131:S75-S80

Hasvold J, Bradford L, Nelson C, Harrison C, Attar M, Stillwell T. Gentamicin resistance among Escherichia coli strains isolated in neonatal sepsis. J Neonatal Perinatal Med. 2013;6(2):173-7. doi: 10.3233/NPM-1365512.


GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

Terri Stillwell, MD: PHIS+: Augmenting the Pediatric Health Information System with Clinical Data 2010-2011

Terri Stillwell, MD: The Impact of a New Antibiotic Stewardship Program on Nosocomial Infection Due to Antibiotic-Resistant Bacteria Research Advisory Committee, Children's Hospital of Pittsburgh of UPMC, 2009-2010

Brian Campfield, MD: Pittsburgh Pediatric Rheumatology Training Grant, 2011-2013

Anna Huppler, MD: Pediatric Infectious Diseases Society Fellowship Award funded by the Stanley A. Plotkin Sanofoi Pasteur Fellowship Award, 2012-2014.

Anna Huppler, MD: Research Advisory Committee of Children's Hospital of Pittsburgh of the UPMC Health System Fellowship Award, 2012.

Benjamin Lee, MD: NIH T32 Grant. The role of interferon responses in influenza-associated Th17 suppression and susceptibility to secondary bacterial pneumonia Biomarkers of influenza severity in children, Children's Hospital of Pittsburgh of UPMC, 2013-2015.


MAJOR FEATURES OF TRAINING PROGRAM: 

This program is designed to prepare pediatricians for an academic career in pediatric infectious diseases. The clinical training features an exceptional variety of infectious disease problems since Children's Hospital of Pittsburgh is the only children's hospital in Western Pennsylvania . CHP is a center for bone marrow and solid organ transplantation, reparative cardiac surgery, cystic fibrosis, and epilepsy, and the care of patients with short-gut syndrome. Thus, the trainees become skilled in the management of serious infections in previously healthy patients and infections in pediatric patients with complex medical problems. There are abundant and diverse opportunities for clinical and laboratory research. The close affiliation with the University of Pittsburgh's Graduate School of Public Health permits advanced course work in statistics and epidemiology, and mentorship by experts in these areas. In addition, close affiliation with the University of Pittsburgh Medical Center's Department of Immunology and Molecular Genetics provides opportunity for research mentorship from experts in these departments with interests in infectious diseases.

 Overview

The Pediatric Infectious Disease Fellowship is an ACGME-approved training program is designed to produce superior academic pediatric infectious disease specialists. The standard fellowship is three years in duration, with the majority of the first year devoted to clinical training and a progressive increase in protected time for research activities over the next two years. The University of Pittsburgh offers a wide variety of research and career specific options: For fellows who see their future in academic clinical education, a Master's or Certificate in Medical Education is available. Degrees in Clinical Research (from certificate to PhD) can also be sought in the Institute for Clinical Research Education at the University. A host of opportunities are available for learning bench research from world-renowned researchers at the University of Pittsburgh (many of whom are on the Children's campus). In addition to a wide variety of clinical and bench research opportunities, the fellows will also actively participate in Infection Prevention and Antimicrobial Stewardship Programs within the Children's Hospital. Limited funds are available for extension of the research activities of fellows to a fourth year of training in order to better prepare the fellow for the assumption of an academic career. U.S. citizenship is not required for application to the fellowship.

Clinical Training

Centered at Children's Hospital of Pittsburgh of UPMC and with close ties to the Adult Infectious Diseases Program at UPMC, the fellowship offers fellows a wide breadth of clinical experience. Because Children's Hospital is the major tertiary pediatric facility in a region that includes western Pennsylvania, southeast Ohio, western Maryland, and West Virginia, the clinical problems seen include entities ranging from the common, such as pneumonia and osteomyelitis; to the unusual, such as zoonotic infections; to the complex, such as rare and mixed infectious diseases in immunosuppressed transplant patients. With an active microbiology and virology laboratory, and in- and outpatient facilities designed for the care of children, the clinical experience of the trainee is quite complete. Moreover, the Pediatric Infectious Disease division maintains an exceptionally strong partnership with the solid organ and stem cell transplant, oncology, and primary immunodeficiency services. Thus, the CHP fellowship program provides outstanding training in the care of immunocompromised patients, especially transplant infectious diseases.


AFFILIATED HOSPITALS: None.

NUMBER OF PEDIATRIC BEDS: 315

FELLOWS ACCEPTED EACH YEAR: 1

TRAINING FOR MD; DO; MD, PhD: Yes

FUNDING IS ENSURED FOR ALL 3 YEARS: Yes

VISAS ACCEPTED: J1, H1B, Other

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? YES

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

Program provides training in diagnostic microbiology using laboratories on site:

Microbiology laboratory: YES
Clinical virus isolation laboratory: YES
Molecular diagnostics: YES

Program provides training in infection control and hospital epidemiology as:

Didactic lectures: YES
Hands on experience: YES
Infection Control Meetings/Membership: YES

Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:

Bacteriology/bacterial infections: YES
Epidemiology and statistics: YES
Infection control/hospital epidemiology: YES
Immunizations/Public health: NO
Mycology/fungal infections: YES
Parasitology/parasitic diseases: NO
Virology/viral diseases: YES
Antimicrobial agents: YES

Research opportunities in the section’s program could be describes as:

Basic (bench): YES
Molecular: YES
Community: YES
Epidemiologic: YES
Clinical: YES
International/Public Health: YES
Health Services: NO
HIV, Basic: NO
ACTG Site: NO

Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: YES

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES

Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES

Program provides substantial clinical experiences for trainees in special areas/hosts:

HIV: YES
Bone marrow transplantation: YES
Solid organ/transplantation: YES
Travelers/adoptees: NO
Adults: YES
Congenital immune deficiencies: YES

Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES

Program has an NIH-sponsored training grant: YES

The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: YES

Average number of new outpatient consultations per month: 5-10

Average number of established outpatient follow-up visits per month: 1-2

Average number of new inpatient consultations per month: 75

Number of trainees completing program in the last 5 years: 5