Children's National Medical Center / GW University Medical School

111 Michigan Avenue, NW
Contact Person: Bernhard L. Wiedermann, MD, MA
Phone: (202) 476-6151
Fax: (202) 476-3850

RESEARCH INTEREST: Medical education, educational technology, telemedicine, evidence-based medicine, pediatric fungal diseases

RESEARCH INTEREST:Basic: Viral Pathogenesis, Viral Myocarditis, Novel Antiviral Therapies, Apoptosis, Genomics; Clinical: Encephalitis, Myocarditis

FACULTY:Joseph Campos, PhD
RESEARCH INTEREST:Clinical Microbiology, Bioinformatics, Molecular Diagnostics

FACULTY:Kathy Ferrer, MD
RESEARCH INTEREST:Adherence and Disclosure in children and adolescents with perinatally acquired HIV infection, Global pediatric HIV infection

FACULTY:Benjamin Hanisch, MD
RESEARCH INTEREST: Pediatric transplant infectious diseases, tropical infectious diseases

FACULTY: Barbara Jantausch, MD
RESEARCH INTEREST:Microbial pathogenesis, UTI, pneumococcal infections, antimicrobial therapeutics

FACULTY:Natella Rakhmanina, MD, PhD
RESEARCH INTEREST:HIV Pharmacology, pharmacogenetics of antiretroviral drugs

FACULTY:Xiaoyan Song, PhD
RESEARCH INTEREST:Epidemiology, Biostatistics

FACULTY:Steve Zeichner, MD
RESEARCH INTEREST:Basic: Immunology of HIV, Microbiotica and Human Infection

FDA FACULTY:Sumathi Nambiar, MD
RESEARCH INTEREST:FDA CDER, Anti-infective Agents and Regulatory Issues

FDA FACULTY:  Wellington Sun, MD
RESEARCH INTEREST: FDA, Vaccines, Devices and Regulatory Issues

RESEARCH INTEREST:FDA CBER, Vaccines, Devices and Regulatory Issues


  • FDA-track fellow projects relate to New Drug and Vaccine Application reviews.
  • Change in epidemiology of health-care associated infections in a neonatal intensive care unit. Pediatr Infect Dis J 2002; 21:839-42.
  • Porin variation among clinical isolates of Neisseria gonorrheae over a 10-year period, as determined by por variable region typing. J Infect Dis 2003;187:1213-1222
  • Discordant clearance of Gram positive and Gram negative bacteria in SLPI null mice. Regulation of the tonsil cytokine milieu favors HIV susceptibility. J Leak Boil 2006; 80:1145-55.
  • Analysis of Vancomycin Associated Drug Rash, Eosinophilia, and Systemic Symptoms (DRESS) Syndrome. 48 thInterscience Conference of Antimicrobial Agents and Chemotherapy/46 thInfectious Disease Society of America Meeting; 1828, 2008.
  • Moraxella catarrhalisBacteremia in Children. 48 thInterscience Conference of Antimicrobial Agents and Chemotherapy/46 thInfectious Disease Society of America Meeting, 2008.
  • Human Parechovirus-3 Infection:  Emerging Pathogen in Neonatal Sepsis.  Pediatr Infect Dis J. 2009; 28(6):545-547.
  • Linezolid associated neuropathy in children. Ninth Annual St. Jude/PIDS Pediatric Microbial Research Conference; 2010.
  • Lyme Disease. In Berman’s Pediatric Decision Making(5 thEdition).  Elsevier. 2010. In press.
  • Eradication of disseminated adenovirus in a BMT recipient with severe graft versus host disease using the novel antiviral agent CMX001. J. Clin. Virol. 2010
  • Regional, and National Assessment of Pediatric Malaria in the United States. Am J Trop Med Hygiene.2011; in press .
  • Neurologic manifestations of pediatric novel H1N1 influenza infection. Pediatr Infect Dis J. 2011.


  •   DeBiasi RL,Robinson BA, Brown RD, Long C, and Clarke P.  Critical role for death receptor-mediated apoptotic signaling in viral myocarditis.   J. Card. Fail. 2010; 16(11):901-10.
  • Rellosa N, Bloch K, Shane A, DeBiasi RL.  Neurologic Manifestations of Pediatric Novel H1N1 Influenza Infection. Ped. Inf. Dis. J.  2010; In press, Aug 31 Epub ahead of publication.
  • Paolino K, Sande J, Perez E, Loechelt B, Jantausch B, Painter W, Fry T and DeBiasi RL.  Eradication of disseminated adenovirus in a BMT recipient with severe graft versus host disease using the novel antiviral agent CMX001. J. Clin. Virol. 2010; In press, Nov 18 Epub ahead of publication
  • DeBiasi RLand Waterman P, reporting authors with Centers for Disease Control and Prevention.  MMWR. Tick-borne encephalitis among US travelers to Europe and Asia --- 2000--2009. 2010; Mar 26; 59(11):335-8.
  • Leyenaar JK, Novosad PM, Ferrer KT,Thahane LK, Mohapi EQ, Schutze GE, Kline MW.  Early Clinical Outcomes in Children Enrolled in Human Immunodeficiency Virus Infection Care and Treatment in Lesotho.  Pediatric Infectious Disease Journal. 2010; 29 (4):340-345.
  • Kim P, Wu Y, Cooper C, Rochester G, Valappil T, Wang Y, Kornegay C,  Nambiar S. Meta-Analysis of a possible signal of increased mortality associated with cefepime use. Clin Infect Dis2010; 51(4):381-389
  • Sorbello A, Komo S, Valappil T, Nambiar S.Registration Trials of Antibacterial Drugs for the treatment of nosocomial pneumonia. Clin Infect Dis. 2010; 51(S1):S36–S41.
  • Neely M, Rakhmanina N. “Pharmacokinetic Optimization of Antiretroviral Therapy in Children and Adolescents”. Clin Pharmacokinet. 2010; In press.
  • Rakhmanina NY, van den Anker JN. Efavirenz in the therapy of HIV infection. Expert Opin Drug Metab Toxicol2010; 6(1):95-103.
  • Neely MN, Rakhmanina NY. Comment on: Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children. J Antimicrobial Chemotherapy2010; 65(4):808-9.
  • Rakhmanina NY, van den Anker JN, Soldin SJ, van Schaik RH, Mordwinkin N, Neely MN. Can Therapeutic Drug Monitoring Improve Pharmacotherapy of HIV Infection in Adolescents? Ther Drug Monit2010; 32(3):273-281.
  • Rakhmanina N, van den Anker J. Treating an HIV-infected pediatric patient: an easy task.  Antivir Ther2010; 15(3):293-6.
  • Neely M, Rakhmanina N.Pharmacokinetic Optimization of Antiretroviral Therapy in Children and Adolescents. Clin Pharmacokinetin press
  • Song X, Perencevich E, Campos JM, Short BL, Singh, N. Clinical and Economic Impact of Methicillin-Resistant Staphylococcus aureus Colonization or Infection on Neonates in Intensive Care Units. Infect Control Hosp Epidemiol. 2010; 31: 177-182
  • Song X,Cheung S, Klontz K, Short BL, Campos J, Singh N.A Stepwise Approach to Control an Outbreak of Methicillin-Resistant Staphylococcus aureusin Neonatal Intensive Care Unit. Am J Inf Control. 2010; 38:607-611.
  • Milstone AM, Song X, Coffin S, Elward A. Identification and Eradication of Methicillin-Resistant Staphylococcus aureus Colonization in the Neonatal Intensive Care Unit: Results of a National Survey.  Infect Control Hosp Epidemiol.2010;31(1).
  • Nalini Singh, Co-Author as a member of Healthcare Infection Control Advisory Committee: Guidelines for prevention of Catheter-associated Urinary Tract Infections. Infect Control Hosp Epidemiol. 2010; 31: 319-326
  • Siegel D, Song X, Klontz K, Pastor W, Singh N. Epidemiology of Childhood Tuberculosis: Use and Evaluation of the Pediatric Health Information System to Assess Local and National Incidence. Pediatr Infect Dis J. 2011; in press
  • Hickey P, Cape K, Masouka P, Campos C, Pastor B, Wong E, Singh N. A Local, Regional, and National Assessment of Pediatric Malaria in the United States. Am J Trop Med Hygiene.2011; in press .
  • Ferrnandez G, Zeichner SL. Cell line-dependent variability in HIV activation employing DNMT inhibitors.  Virol J.2010; 7:266

MAJOR FEATURES OF TRAINING PROGRAM:Our goals are to provide well-rounded training for fellows in clinical pediatric infectious diseases and in medical research. Successful completion of our ACGME-accredited program will provide the individual with the necessary qualifications for a position as a board-certified pediatric infectious diseases specialist.

Our program consists of three tracks, including two FDA Tracks affiliated with the United States Food and Drug Administration and a Traditional Track. Clinical training is identical for both tracks, with the tracks differing in research training focus.


Clinical experiences for fellows comprise a total of one-third of the 3-year training program and occur at the Sheikh Zayed Campus for Advanced Children's Medicine of Children's National Health System in Washington, DC. Children's Hospital is a 313-bed facility that has served the nation's capital for over 140 years. Included in these beds are a Level IIIC Neonatal Intensive Care Unit, a Pediatric Intensive Care Unit, a Cardiac Intensive Care Unit, a Neurologic Intensive Care Unit, a Hematopoietic Stem Cell Transplant Unit, and a Level I Trauma Center. We admit over 13,000 children annually and provide more than 350,000 outpatient visits per year. Our Infectious Diseases service sees approximately 30 new and 100 follow-up visits monthly in our outpatient clinic, with over 100 inpatient consult visits per month. We accept up to three new fellows into the program each year.

Our infectious diseases practice reflects a highly diverse patient population, with children residing in the mid-Atlantic region as well as those originating or traveling from sites across the United States and the world. We care for children with not only common pediatric infections such as pneumonia and osteomyelitis, but also conditions including malaria, typhoid fever, and other tropical diseases, endemic infections such as Lyme Disease and Rocky Mountain Spotted Fever, and infections in compromised hosts. Our fellows actively participate in our Special Immunology Service, providing subspecialty and primary care to HIV-exposed and infected children.


Fellows may pursue a wide variety of opportunities for research training in clinical, basic science, epidemiologic and outcomes research. We currently sponsor joint fellowship training programs with the National Institutes of Health (NIH), and the Food and Drug Administration (FDA). The program also has adjunct faculty with international health experience who are available to mentor fellows. Fellows pursuing a basic science focus may find mentors at the NIH, as well as Children's Research Institute (CRI) or GWU. Fellows pursuing clinical research may perform research at CNMC, as well as via the FDA track, in which fellows gain regulatory experience at the FDA in the divisions of anti-infective agents, antivirals and special pathogens. CRI, including a Pediatric GCRC, is integated within CNMC, faciliatating close relationships between investigators and clinicians, and research by physician-scientists, including over 20 K-awardees. Fellows may elect to earn a Master’s Degree in Public of Health from George Washington University .

AFFILIATED HOSPITALS: Children's National Medical Center (CNMC)




FUNDING IS ENSURED FOR ALL 3 YEARS: Yes for all 3 tracks

VISAS ACCEPTED: J1, H1B, Other (FDA tracks must be US citizens or green card holders per federal regulations)



Program provides training in diagnostic microbiology using laboratories on site:

Microbiology laboratory: YES
Clinical virus isolation laboratory: YES
Molecular diagnostics: YES
Other – Please specify: Daily rounds with Director of Microbiology Lab and formal Microbiology block rotation

Program provides training in infection control and hospital epidemiology as:

Didactic lectures: YES
Hands on experience: YES
Infection Control Meetings/Membership: YES

Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:

Bacteriology/bacterial infections: YES
Epidemiology and statistics: YES
Infection control/hospital epidemiology: YES
Immunizations/Public health: YES
Mycology/fungal infections: YES - through affiliated programs
Parasitology/parasitic diseases: YES
Virology/viral diseases: YES
Antimicrobial agents: YES
Other – Please specify:

Research opportunities in the section’s program could be describes as:

Basic (bench): YES
Molecular: YES
Translational: YES
Epidemiologic: YES
Clinical: YES
International/Public Health: YES
Health Services: YES
HIV, Basic: YES
HIV, Clinical: Y ES
Other – Please specify:

Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: YES

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES

Other – Please specify: Master's in bioinformatics, other fields also available

Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES

Program provides substantial clinical experiences for trainees in special areas/hosts:

Bone marrow transplantation: YES
Solid organ/transplantation: YES
Travelers/adoptees: YES
Adults: Minimal - related to adults with congenital heart diseease/transplant, cystic fibrosis
Congenital immune deficiencies: YES
Other – Please specify:

Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES

Program has an NIH-sponsored training grant: YES - for selected areas of research

The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: YES (Special Immunology subdivision of ID division)

Average number of new outpatient consultations per month: 40

Average number of established outpatient follow-up visits per month: 100

Average number of new inpatient consultations per month: 85

Number of trainees completing program in the last 5 years: (2010-2015): 10