University of California, San Francisco

Division of Pediatric Infectious Diseases, Box 0434 550 16th Street, 4th Floor
San Francisco
CA
94158
USA
Contact Person: Julie Tran
Phone: (415) 502-3243
Fax: (415) 476-5354

TRAINING PROGRAM DIRECTOR: Theodore Ruel, MD
RESEARCH INTEREST: HIV treatment and implementation, global neonatal health

FELLOWSHIP PROGRAM COORDINATOR: Julie Tran

CHIEF OF INFECTIOUS DISEASES: Theodore Ruel, MD

ASSOCIATES/DIVISION MEMBERS:

  • Peggy Weintrub, MD
    Research Interests: Clinical infectious diseases
     
  • Margaret Feeney, MD
    Research Interests: Malaria and HIV immunology, global health
     
  • Lynn Ramirez, MD
    Research Interests: Infection prevention
     
  • Rachel Wattier, MD
    Research Interests: Infections in immunocompromised hosts and antimicrobial stewardship
     
  • Mary Prahl, MD
    Research Interests: Malaria and developmental immunology, global health
     
  • Manjiree Karandikar
    Research Interests: Infections in immunocompromised hosts and antimicrobial stewardship

TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS: 

Medzihradsky OF, Kleinschmidt I, Mumbengegwi D, Roberts KW, McCreesh P, Dufour MK, Uusiku P, Katokele S, Bennett A, Smith J, Sturrock H, Prach LM, Ntuku H, Tambo M, Didier B, Greenhouse B, Gani Z, Aerts A, Gosling R, Hsiang MS. Study protocol for a cluster randomised controlled factorial design trial to assess the effectiveness and feasibility of reactive focal mass drug administration and vector control to reduce malaria transmission in the low endemic setting of Namibia. BMJ Open, 8(1):e019294, 2018 Jan.

Farrington L, Vance H, Rek J, Prahl M, Jagannathan P, Katureebe A, Arinaitwe E, Kamya MR, Dorsey G, Feeney ME. Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children. Malaria Journal, 16(1):499, 2017 Dec.

Prahl M, Jagannathan P, McIntyre TI, Auma A, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Odorizzi P, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME. Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero. Open forum infectious diseases, 4(1):ofx022, 2017 Feb.

Prahl M, Jagannathan P, McIntyre TI, Auma A, Farrington L, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Vance H, Odorizzi P, Nayebare P, Ategeka J, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME. Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation. Malaria Journal, 5(1):497, 2016 Oct.

Wattier RL, Dvorak CC, Auerback A, Weintrub P (2015). Repeat blood cultures in children with persistent fever and neutropenia: Diagnostic and clinical implications. Pediatric Blood Cancer, 2015 Aug; 62(8): 1421-6.

Kussmaul S, Horn B, Dvorak C, Abramovitz L, Cowan M, Weintrub P (2010). Safety of the live, attenuated varicella vaccine in pediatric recipients of hematopoietic stem cell transplants. Bone Marrow Transplant, 2010 Nov; 45(11):1602.

Baltzell KA, Shakely D, Hsiang MS, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B, Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar, American Journal of Tropical Medicine and Hygiene, Feb; 88(2): 289-91, 2013.

Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE. Pulmonary Coccidiomycosis Masquerading as Refractory Metastatic Ewing Sarcoma. J Pediatr Hematol Oncol, Apr 11, 2013.

Hsiang MS, Hwang J, Kunene K, Drakeley C, Parizo J, Jensen T, Tong M, Kandula D, Novotny J, Kemere J, Ockenhouse C, Engov E, Dlamini S, Dorsey G, Greenhouse B, Approaching Malaria Elimination in Swaziland: Use of a PCR-based pooling strategy and Serology in a National Cross-sectional Survey, PLOS ONE, 7(1), 2012, e29550.

Hsiang MS, Shiau R, Nadle J, Chan L, Lee B, Chambers HF, Pan E. Few Factors Distinguish Pediatric Community-Associated Methicillin-Resistant from Methicillin-Sensitive Staphylococcus aureus Infections: a Case Comparison Study in San Francisco Bay Area, Journal of Pediatric Infectious Diseases Society, 1(3): 200-211, 2012.

Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, Drakeley C, Primaquine in Africa Discussion Group. Rationale for short course primaquine in Africa to interrupt malaria transmission, Malaria Journal, 11(360), 2012.

Hsiang M, Carlton E, Zhang Y, Bo Z, Qiu D, Cohen P, Stewart C, Spear R. Use of Ultrasonography to Evaluate Schistosoma japonicum- related Morbidity in Children, Sichuan Province, China, 2007. American Journal of Tropical Medicine and Hygiene 82(1), 2010.

Hsiang MS, Abeyasinghe R, Whittaker M, Feachem RGA. Malaria Elimination in the Asia-Pacific: an under-told story. Lancet, 375(9726), 2010.

Carlton EJ, Hsiang MS, Zhang Y, Johnson S, Hubbard A, Spear RC. The impact of Schistosoma japonicum infection on ultrasound-detectable liver and spleen pathology, results from a five-year longitudinal cohort in Southwest China. PLOS Neglected Tropical Diseases, 4(5), 2010.

Hsiang MS, Lin M, Dokomajilar C, Kemere J, Pilcher CD, Dorsey G, and Greenhouse B. PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children, Journal of Clinical Microbiology, 48(10), 2010.

Sabot O, Cohen JM, Hsiang MS, Kahn JG, Basu S, Tang L, Zheng B, Gao Q, Zou L, Tatarsky A, Aboobakar S, Usas J, Barrett S, Cohen JL, Jamison DT, Feachem RGA, Costs and financial feasibility of malaria elimination, Lancet, 376(9752):1604-15, 2010.

R. Wattier, C. Dvorak, J. Hoffman, A. Brozovich, I. Bin-Hussain, A. Groll, E. Castagnola, K. Knapp, T. Zaoutis, B. Gustafsson, L. Sung, D. Berman, N. Halasa, M. Abzug, A. Velegraki, T. Sharma, B. Fisher. W. Steinbach. A Prospective, International Cohort Study of Invasive Mold Infections in Children. J Pediatr Infect Dis. (in press)

Winger B, Foy E, Sud S, MacKenzie J, Pua H, Lau A, Heyman J, Laszik Z, Tureen J. Mycobacterium bovis enterocolitis in an immunocompromised host. The Journal of Pediatric Gastroenterology and Nutrition. (in press)


GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS: 

  • Pediatric Scientist Development Program Fellowship, 2018-2020
  • Clinical and Translational Science Institute TL1 Prescient Fellowship, 2017-2019
  • Thrashers Early Career Award, 2017-2019
  • IDSA Pfizer Fellowship Award, 2014- 2016
  • Infectious Disease Society of America, Merle A. Sande/Pfizer Fellowship Award in International Infectious Diseases, 2014-15.
  • T32 NIH HIV Translational Training Grant, 2014 - 2015
  • Early Career Award, Thrasher Research Foundation, 2013-2015.
  • UCSF Caring Wisely Pilot Award, 2013-2014.
  • Burroughs Wellcome Fund – American Society of Tropical Medicine and Hygiene, 2012-2014.
  • Gates Foundation Grand Challenges Explorations Grant, Round 3, 2009-2011.
  • Pediatric Infectious Diseases Society (PIDS) Fellowship Award, 2008-2010.
  • In addition to the above, fellows are frequently awarded positions on NIH T32 grants held outside of our division, including the years of 2012-2015.

MAJOR FEATURES OF TRAINING PROGRAM:

This is three-year program geared to prepare fellows for careers in academic infectious diseases. The first year is focused on clinical training at the UCSF Benioff Children’s Hospital, including general and immunocompromised populations. In the second and third years, fellows complete clinical rotations in outpatient subspecialty clinics but devote the majority of time to research. For research mentorship, fellows can work within our division or with any of UCSF’s world-class researchers in the basic and clinical sciences.

HOSPITALS PARTICIPATING IN PROGRAM: 

UCSF Benioff Children's Hospital, San Francisco: 183 beds

UCSF Benioff Children's Hospital, Oakland: 191 beds 

FELLOWS ACCEPTED EACH YEAR: 1
 
TRAINING FOR: MD; DO; MD, PhD
 
FUNDING IS ENSURED FOR ALL 3 YEARS: Yes
 
VISAS ACCEPTED
 
IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? YES

THE PROGRAM OFFERS THE FOLLOWING TRAINING:  

  • Program provides training in diagnostic microbiology using laboratories on site:
    • Microbiology laboratory:  YES
    • Clinical virus isolation laboratory: YES
    • Molecular diagnostics: YES
       
  • Program provides training in infection control and hospital epidemiology as:
    • Didactic lectures:  YES
    • Hands on experience: YES
    • Infection Control Meetings/Membership: YES
       
  • Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:
    • Bacteriology/bacterial infections: YES
    • Epidemiology and statistics: YES
    • Infection control/hospital epidemiology: YES
    • Immunizations/Public health: YES
    • Mycology/fungal infections: YES
    • Parasitology/parasitic diseases: YES
    • Virology/viral diseases: YES
    • Antimicrobial agents: YES
       
  • Research opportunities in the section’s program could be describes as:
    • Basic (bench): YES
    • Molecular: YES
    • Community: YES
    • Epidemiologic: YES
    • Clinical: YES
    • International/Public Health: YES
    • Health Services: YES
    • HIV, Basic: YES
    • HIV, Clinical: YES
    • ACTG Site: YES  
       
  • Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: YES
     
  • Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES
     
  • Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES
     
  • Program provides substantial clinical experiences for trainees in special areas/hosts:
    • HIV: YES
    • Bone marrow transplantation: YES
    • Solid organ/transplantation: YES
    • Travelers/adoptees: YES
    • Adults: YES
    • Congenital immune deficiencies: YES
       
  • Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES
     
  • Program has an NIH-sponsored training grant: NO
     
  • The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: NO
     
  • Average number of new outpatient consultations per month: 20
     
  • Average number of established outpatient follow-up visits per month: 20
     
  • Average number of new inpatient consultations per month: 75
     
  • Number of trainees completing program in the last 5 years: 5