Children's Hospital Los Angeles

4650 Sunset Boulevard, MS #51
Los Angeles
CA
90027
USA
Phone: (323) 361-2509
Fax: (323) 361-1183

TRAINING PROGRAM DIRECTOR: Pia S. Pannaraj, MD, MPH (Associate Professor)
RESEARCH INTEREST: Maternal Immunizations, Influenza Epidemiology, Influenza Vaccination Strategy, Herd Immunity, Neonatal Infections, Gut microbiome in the developing infant, Breast milk microbiome
http://www.chla.org/profile/pia-pannaraj-md-mph 

CHIEF OF INFECTIOUS DISEASES: Michael Neely, MD (Associate Professor)
RESEARCH INTEREST: Personalized medicine and optimal dosing of antimicrobial agents and other therapeutic drugs; Anti-bacterial, anti-viral and anti-fungal pharmacology, Pediatric clinical pharmacology; Pediatric drug development.
http://www.chla.org/profile/michael-neely-md-msc-fcp#quickset-profile1 

  ASSOCIATE/DIVISION MEMBERS

  • Jill A. Hoffman, MD (Associate Professor)
    RESEARCH INTEREST: Infections in immunocompromised hosts, Transplant infectious diseases, Aspergillus infections, Streptococcus pneumoniae Infections
    http://www.chla.org/profile/jill-hoffman-md 
     
  • Jeffrey Bender, MD (Assistant Professor)
    RESEARCH INTEREST: Microbiome and how interactions with indigenous microbial communities may translate to novel preventative and therapeutic approaches to pediatric disease; Hospital epidemiology; New technologies in the microbiology lab and how they can be translated to powerful clinical tools in a pediatric setting
    http://www.chla.org/profile/jeffrey-bender-md 
      
  • Kanok Mongkolrattanothai, MD (Associate Professor)
    RESEARCH INTEREST:Staphylococcus aureus virulence and pathogenesis, Antimicrobial stewardship
    http://www.chla.org/profile/kanokporn-mongkolrattanothai-md 
  • Presadarao Nemani, PhD (Professor)
    RESEARCH INTEREST: Pathogenesis of neonatal meningitis by E. coli, Listeria and Group B streptococcus; Pathogenesis of Cronobacter sakazakii induced necrotizing enterocolitis and meningitis; Development of small molecule therapeutics; Interaction of complement proteins and immune cells with various bacterial pathogens; and Molecular modeling of ligand-receptor interactions.
    http://www.chla.org/profile/prasadarao-nemani-phd 
  • Sheng-He Huang, PhD (Associate Professor)
    RESEARCH INTEREST: Pathogenesis of central nervous system infection; Infectomics: Integration of system biology and omic approaches in the field of infectious diseases; Theory and Practice of Medical System Biology; Digital Genomic Medicine (education and research) 

TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OF RESEARCH PROJECTS:

Influenza Vaccine is Protective Against Laboratory-confirmed Influenza in Obese Children.
Smit MA, Wang HL, Kim E, Barragan N, Aldrovandi GM, Nelson El Amin A, Mascola L, Pannaraj PS. 
Pediatr Infect Dis J. 2016 Apr;35(4):440-5. doi: 10.1097/INF.0000000000001029.
PMID: 26658380

Transition of care and health-related outcomes in pediatric onset systemic lupus erythematosus.
Felsenstein S, Reiff AO, Ramanathan A.
Arthritis Care Res (Hoboken). 2015 May 4. doi: 10.1002/acr.22611. [Epub ahead of print] PMID: 25939495

Pediatric carbapenem-resistant Enterobacteriaceae in Los Angeles, California, a high-prevalence region in the United States.
Pannaraj PS, Bard JD, Cerini C, Weissman SJ.
Pediatr Infect Dis J. 2015 Jan;34(1):11-6. doi: 10.1097/INF.0000000000000471.
PMID: 25093977

Clinical and microbiologic outcomes of quinolone prophylaxis in children with acute myeloid leukemia.
Felsenstein S, Orgel E, Rushing T, Fu C, Hoffman JA.
Pediatr Infect Dis J. 2015 Apr;34(4):e78-84. doi: 10.1097/INF.0000000000000591. PMID: 25764103

Molecular and clinical diagnosis of group A streptococcal pharyngitis in children.
Felsenstein S, Faddoul D, Sposto R, Batoon K, Polanco CM, Dien Bard J.
J Clin Microbiol. 2014 Nov;52(11):3884-9. doi: 10.1128/JCM.01489-14. Epub 2014 Aug 20. PMID: 25143573

Direct identification of bacteria from positive BacT/ALERT blood culture bottles using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry.
Mestas J, Felsenstein S, Bard JD.
Diagn Microbiol Infect Dis. 2014 Nov;80(3):193-6. doi: 10.1016/j.diagmicrobio.2014.07.008. Epub 2014 Jul 31. PMID: 25139844

School-located influenza vaccination decreases laboratory-confirmed influenza and improves school attendance.
Pannaraj PS, Wang HL, Rivas H, Wiryawan H, Smit M, Green N, Aldrovandi GM, El Amin AN, Mascola L.
Clin Infect Dis. 2014 Aug 1;59(3):325-32. doi: 10.1093/cid/ciu340. Epub 2014 May 14.
PMID: 24829215

Performance of the Verigene Gram-positive blood culture assay for direct detection of Gram-positive organisms and resistance markers in a pediatric hospital.
Mestas J, Polanco CM, Felsenstein S, Dien Bard J.
J Clin Microbiol. 2014 Jan;52(1):283-7. doi: 10.1128/JCM.02322-13. Epub 2013 Oct 16. PMID: 24131696

Human parechovirus central nervous system infections in southern California children.
Felsenstein S, Yang S, Eubanks N, Sobrera E, Grimm JP, Aldrovandi G.
Pediatr Infect Dis J. 2014 Apr;33(4):e87-91. doi: 10.1097/INF.0000000000000112. PMID: 24104958

Clinical and microbiologic features guiding treatment recommendations for brain abscesses in children.
Felsenstein S, Williams B, Shingadia D, Coxon L, Riordan A, Demetriades AK, Chandler CL, Bassi S, Koutoumanou E, Stapleton S, Sharland M, Bryant PA.
Pediatr Infect Dis J. 2013 Feb;32(2):129-35. doi: 10.1097/INF.0b013e3182748d6e. PMID: 23001027

Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies.
Nakamura KJ, Cerini C, Sobrera ER, Heath L, Sinkala M, Kankasa C, Thea DM, Mullins JI, Kuhn L, Aldrovandi GM.
AIDS. 2013 Jan 28;27(3):337-46. doi: 10.1097/QAD.0b013e32835cadd6.
PMID: 23296195

J Pediatr Orthop. 2010 Dec;30(8):893-8. doi: 10.1097/BPO.0b013e3181fbebe5.
Increased incidence of sacroiliac joint infection at a children's hospital.
Taylor ZW1, Ryan DD, Ross LA.

Survival and transmission of community-associated methicillin-resistant Staphylococcus aureus from fomites.
Desai R, Pannaraj PS, Agopian J, Sugar CA, Liu GY, Miller LG.
Am J Infect Control. 2011 Apr;39(3):219-25. doi: 10.1016/j.ajic.2010.07.005.
PMID: 21458684

The role of bronchoalveolar lavage galactomannan in the diagnosis of pediatric invasive aspergillosis.
Desai R, Ross LA, Hoffman JA.
Pediatr Infect Dis J. 2009 Apr;28(4):283-6. doi: 10.1097/INF.0b013e31818f0934.
PMID: 1923811

MAJOR FEATURES OF TRAINING PROGRAM:
Our three-year program is designed to train fellows for positions in academic infectious diseases and to qualify them for subspecialty boards in pediatric infectious diseases. In addition, we welcome those interested in global health. Clinical training involves infectious diseases seen in a large free standing children’s hospital. This includes inpatient and outpatient consultations and participation in scheduled Infectious Diseases and Immunology clinics. There may be opportunities for clinical infectious disease rotations in other countries particular in Latin America and Asia. The program includes formal training in clinical microbiology, (virology, bacteriology, mycology, parasitology, and serology), as well as participation in department academic pediatric courses, which include epidemiology, study design, biostatistics, and grant writing. Research is an integral part of the program in all three years. Fellows may work with mentors in different departments at CHLA and USC depending on their interest. Our research projects have considerable variability and include clinical studies with supportive laboratory research and basic molecular biologic studies. Present areas of research include studies relating to pathogenesis of HIV, mother-to child transmission of HIV, mucosal immunology, infant microbiome, maternal immunization, vaccination strategies, epidemiology of respiratory viruses, e. coli pathogenesis infections in immunocompromised hosts, transplant infections antifungal parmacokinetics, antibacterial sterwardship, and infection control strategies.

AFFILIATED HOSPITALS:USC University Hospital
NUMBER OF PEDIATRIC BEDS:347
FELLOWS ACCEPTED EACH YEAR:1 to 2
TRAINING FOR: MD, DO, MD, PhD
FUNDING ENSURED FOR ALL 3 YEARS: YES
VISAS ACCEPTED: J1, H1B
IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT?

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

  • Program provides training in diagnostic microbiology using laboratories on site:
    • Microbiology laboratory
    • Clinical virus isolation laboratory
    • Molecular diagnostics
  • Program provides training in infection control and hospital epidemiology as:
    • Didactic lectures
    • Hands on experience
    • Infection Control Meetings/Membership
  • Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:
    • Bacteriology/bacterial infections
    • Epidemiology and statistics
    • Infection control/hospital epidemiology
    • Immunizations/Public health
    • Mycology/fungal infections
    • Parasitology/parasitic diseases
    • Virology/viral diseases
    • Antimicrobial agents
  • Research opportunities in the section's program could be described as:
    • Basic (bench)
    • Molecular
    • Community
    • Epidemiologic
    • Clinical
    • International/Public Health
    • Health Services
    • HIV, Basic
    • ACTG Site
  • Documented liaison exists offering opportunities for research experience in the laboratory of investigators(s) who is (are) not faculty of the section: YES
     
  • Program offers the opportunity to obtain a Master's degree in a field such as Public Health, Education, Clinical Sciences or Epidemiology: YES
     
  • Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES
     
  • Program provides substantial clinical experience for trainees in:
    • HIV
    • Bone marrow transplantation
    • Solid organ/transplantation
    • Travelers/adoptees
  • Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers: YES
  • Average number of new outpatient consultations per month:30
  • Average number of established outpatient follow-up visits per month:135
  • Average number of new inpatient consultations per month: 60
  • Number of trainees completing program in the last 5 years: 5
Located in: Canada