University of Alabama at Birmingham

114 Children's Harbor Building, 1600 Seventh Avenue South
Birmingham
AL
35233
USA
Phone: (205) 996-7765
Fax: (205) 975-6549

TRAINING PROGRAM DIRECTOR: Masako Shimamura, MD
RESEARCH INTERESTS: transplant infectious diseases

TRAINING PROGRAM ASSISTANT DIRECTOR:  Suresh Boppana, MD          Research Interests:  congenital CMV and hearing loss

CHIEF OF INFECTIOUS DISEASES: Richard Whitley, MD
RESEARCH INTEREST: Herpes simplex: vaccines, therapy, genetically engineered viruses; varicella-zoster virus therapies and models

ASSOCIATE: Russell D. Bradford, MD
RESEARCH INTEREST: Mechanisms of CMV related neurologic damage and CMV neurovirulence in animal models

ASSOCIATE: William J Britt, MD
RESEARCH INTERST: CMV infections; virology; pathogenesis

ASSOCIATE: Kevin Cassady, MD
RESEARCH INTEREST: Molecular mechanisms of HSV pathogenesis

ASSOCIATE: Marilyn J Crain, MPH, MD
RESEARCH INTEREST: HIV in children and families; streptococcus pneumoniae: surface protein antigens; genetic variation; antimicrobial resistance

ASSOCIATE: Karen B Fowler, DrPH
RESEARCH INTEREST: CMV infection; hearing loss; epidemiology; data management

ASSOCIATE: S Cecelia Hutto, MD
RESERACH INTEREST: Epidemiology of perinatal viral infections; natural history of HIV infection in children Antivirals; animal models; pathogenesis of herpesvirus infections

ASSOCIATE: Earl R Kern, PhD
RESEARCH INTEREST: Antivirals; animal models; pathogenesis of herpesvirus infections

ASSOCIATE: David Kimberlin, MD
RESEARCH INTEREST: Natural history and pathogenesis of congenital and perinatally acquired viral infections

ASSOCIATE: Fred Lakeman, PhD
RESEARCH INTEREST: Diagnosis of herpersvirus infections; antiviral resistance; diagnostic virology

ASSOCIATE: Jackie Parker, PhD
RESEARCH INTEREST: Engineered herpes simplex virus for therapeutic and prophylactic use

ASSOCIATE: Robert F Pass, MD
RESEARCH INTEREST: Maternal and congenital CMV infections; CMV vaccines

ASSOCIATE: Mark Prichard, PhD
RESEARCH INTEREST: Antivirals, mechanism of action, molecular virology

ASSOCIATE: Debra Quinnelle, PhD
RESEARCH INTEREST: Development of antiviral therapies against herpesviruses and other viruses

ASSOCIATE: Shannon A. Ross, MD
RESEARCH INTEREST: Pathogenesis of Cogenital CMV Infections

ASSOCIATE: Masako Shimamura, MD
RESEARCH INTEREST: Pathogenesis of CMV infection in transplant recipients

ASSOCIATE: Sergio B Stagno, MD
RESEARCH INTEREST: CMV and HSV perinatal transmission and epidemiology

ASSOCIATE: Wayne M Sullender, MD
RESEARCH INTEREST: Respiratory syncytial virus: genetic and antigenic variability; Human metapneumovirus

ASSOCIATE: Craig M Wilson, MD
RESEARCH INTEREST: Adolescent HIV; low cost, sustainable interventions to reduce HIV vertical transmission; molecular epidemiology of HIV ART resistance

TITLE(S) OF RECENT FELLOWS' PUBLISHED PAPERS OR RESEARCH PROJECTS: Shimamura M, Saunders U, Rha B, Guo L, Cassady K, Georget JF, Britt WJ.  Ganciclovir Prophylaxis Reduces Murine Cytomegalovirus Associated Renal Allograft Inflammation.  48th Annual Meeting of the Infectious Diseases Society of American.  Vancouver, BC.  October 23, 2010.

Saunders U, Rha B, Guo LL, George JF, Britt WJ, Shimamura M. Ganciclovir attenuates murine  cytomegalovirus associated renal allograft inflammation.  XXIII International Congress of The Transplantation Society, accepted 2010.

Widener RW, King JD, Nahm MH, Phillip MT, Alderson M, Briles DE.  Development of a Diagnostic Assay for Detection of Invasive Pneumococcal Disease Using PcpA.  Abstract submitted to 48th Annual Meeting of the Infectious Diseases Society of America, Oct. 21-24, 2010.

Pinninti SG, Feja KN, Kimberlin DW, Leach CD, Conrad DA, McCarthy CA,   Tolan RW.  Neonatal Herpes Disease Despite Maternal Antenatal Antiviral Suppressive Therapy: A Multicenter Case Series of the First Such Infants Reported.  48th Annual Meeting of the Infectious Diseases Society of America.  Vancouver, BC.  October 22, 2010.

Rha R, Redden DT, Benfield M, Lakeman FD, Whitley RJ, Shimamura M.  Correlation of pp65 Antigenemia and Quantitative Polymerase Chain Reaction for the Detection of Cytomegalovirus Infection in Pediatric Renal Transplant Patients. 48th Annual Meeting of the Infectious Diseases Society of America, Oct. 22, 2010. 

James SH, Daily SL, Lakeman F, Prichard MN. Surveillance of Oseltamivir Resistance in 2009 Pandemic Influenza A (H1N1) Viruses via Quantitative Real-Time RT-PCR. St. Jude/PIDS Pediatric Infectious Diseases Research Conference, February 11-13, 2010.

 

James SH.  Recombinant Phenotyping of Cytomegalovirus containing Novel UL54 

        and UL97 Mutations.  Child Health Investigative Forum, Department of

        Pediatrics.  July 16, 2010.  

James SH, Daily SL, Lakeman F, Pritchard MN.  Detection of the H275Y Mutation in 2009 Pandemic Influenza A (H1N1) Viruses Using An Allele-Specific Quantitative Real-Time RT-PCR.  48th Annual Meeting of the Infectious Diseases Society of America, Vancouver, BC.  October 22, 2010. 

James S, Hartline CB, Shannon L, Daily SL, Frederick SL, Kimberlin DW, Whitley R, Prichard MN.  Genotypic Resistance Testing of Cytomegalovirus DNA in Congenitally Infected Infants after 6 Weeks of Antiviral Therapy. 47th Annual Meeting of the Infectious Disease Society of America (IDSA), Philadelphia, PA, October 2009. 

Dumois JA, James SH, Messina AF, Berman DM. Assessment of Healthcare Worker Knowledge of Correct Interpretation of Tuberculin Skin Testing. 48th Annual ICAAC/46th Annual IDSA Meeting, Washington DC, October 25-28, 2008. 

Shalabi M, Abughlai N, Abzug M, Bradley J, Cloud G, Englund J, Griffin J, Guzman-Cottrill J, Jacobs R, Jester P, Lang D, Leach C, Robinson J, Romero J, Sanchez P, Shelton M, Storch G, Wade K, Whitley R, Kimberlin D for the NIAID Collaborative Antiviral Study Group.  Safety of Oseltamivir vs. Amantadine or Rimantadine in Children Under 1 Year of Age.  Infectious Disease Society of America Annual Meeting, San Diego, CA, Oct 2007.

MAJOR FEATURES OF TRAINING PROGRAM: Guided by philosophy that the principal role of the pediatric I.D. specialist is to improve understanding of the pathogenesis, prevention and treatment of infectious diseases, this program places a high priority on developing research skills in trainees. The majority of the fellowship is devoted to research in extramurally supported laboratories under the direction of faculty in pediatric I.D. or basic science departments. Through a departmental Child Health Center award from NIH, it is possible for outstanding fellows to extend training to the junior faculty level. Clinical training is broad and deep, taking advantage of active University Hospital and Children's Hospital services that provide experience with the full range of infectious diseases problems.

AFFILIATED HOSPITALS: The Children’s Hospital of Alabama ; University Hospital (UAB)
NUMBER OF PEDIATRIC BEDS: 360

FELLOWS ACCEPTED EACH YEAR: 1-2

TRAINING FOR: MD; DO; MD, PhD

FUNDING ENSURED FOR ALL 3 YEARS: Yes

VISAS ACCEPTED: J1, H1B, Other

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? YES

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

Program provides training in diagnostic microbiology using laboratories on site:

Microbiology laboratory: YES
Clinical virus isolation laboratory: YES
Molecular diagnostics: YES
Other – Please specify:

Program provides training in infection control and hospital epidemiology as:

Didactic lectures: YES
Hands on experience:
YES
Infection Control Meetings/Membership: YES

Opportunity
to fulfill the ABP requirements for scholarly activity is available in the following general areas:

Bacteriology/bacterial infections: YES
Epidemiology and statistics: YES
Infection control/hospital epidemiology: YES
Immunizations/Public health: YES
Mycology/fungal infections: YES
Parasitology/parasitic diseases: YES
Virology/viral diseases: YES
Antimicrobial agents: YES
Other – Please specify:

Research opportunities in the section’s program could be describes as:

Basic (bench): YES
Molecular: YES
Translational: YES
Epidemiologic: YES
Clinical: YES
International/Public Health: YES
Health Services: NO
HIV, Basic: YES
HIV, Clinical: YES
ACTG Site: YES
Other – Please specify:

Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: YES

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES
Other – Please specify:

Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES

Program provides substantial clinical experiences for trainees in special areas/hosts:

HIV: YES
Bone marrow transplantation: YES
Solid organ/transplantation: YES
Travelers/adoptees: YES
Adults: YES
Congenital immune deficiencies: YES
Other – Please specify:
Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES

Program has an NIH-sponsored training grant: YES

The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: YES
Average number of new outpatient consultations per month:    18
Average number of established outpatient follow-u visits per month:   12
Average number of new inpatient consultations per month:  35

Number of trainees completing program in the last 5 years: (2002-2007) 7