Seattle Children's Hospital / University of Washington

4800 Sand Point Way NE, MA.7.226
Seattle
WA
98105
USA
Contact Person: Courtney Nichols
Phone: (206) 987-6352
Fax: (206) 987-3890

TRAINING PROGRAM DIRECTOR
Matthew Kronman, MD, MSCE

CHIEF OF INFECTIOUS DISEASES
Danielle Zerr, MD, MPH

ASSOCIATES/DIVISION MEMBERS:

  • Serge Barcy, PhD
  • Marta Bull, PhD
  • Jane Burns, MD
  • Claudia Crowell, MD
  • Janet Englund, MD
  • Lisa Frenkel, MD
  • Rafael Hernandez, MD, PhD
  • Heather Jaspan, MD, PhD
  • Jai Lingappa, MD, PhD
  • Ann Melvin, MD, MPH
  • Lakshmi Rajagopal, PhD
  • Timothy Rose, PhD
  • Sherilyn Smith, MD
  • Glen Tamura, MD, PhD
  • Kevin Urdahl, MD, PhD
  • Sara Vora, MD, MPH
  • Alpana Waghmare, MD
  • Thor Wagner, MD
  • Scott Weissman, MD

Research training opportunities include (among others):
Respiratory viruses including influenza virus vaccines, respiratory viruses in immunocompromised patients, Viral evolution of HIV during infection and treatment; Clinical studies of HIV infection; Molecular biology of tumor viruses, cytokines, cell growth, differentiation and transformation; Lung infections in Cystic Fibrosis; Immune response to Mycobacterium tuberculosis infection; Evolution and epidemiology of virulence and antimicrobial resistance in extra intestinal pathogens such as Escherichia coli and Kiebsiella pneumoniae

TITLE(S) OF RECENT FELLOWS' PUBLISHED PAPERS OR RESEARCH PROJECTS:

  1. Duarte HA, Harris DR, Tassiopoulos K, Leister E, Negrini SF, Ferreira FF, Cruz ML, Pinto J, Allison S, Hazra R; NISDI PLACES Study Group. Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America. Braz J Infect Dis. 2015 Mar 3. Pii: S1413-8670(15)000056-2. PMID: 25743569
     
  2. Thiara DK, Ying LC, Raman F, Mangat S, Purdy JB, Duarte HA, Schmidt N, Hur J, Sibley CT, Bluemke DA, Hadigan C. Abnormal myocardial function is related to myocardial steatosis and diffuse myocardial fibrosis in HIV. J Infect Dis. 2015 May 11. PMID: 25964507
     
  3. Patel AS, Bruce M, Harrington W, Portman MA. Coronary artery stenosis risk and time course in Kawasaki disease patients: experience at a US tertiary pediatric centre. Open Heart. 2015 Mar 17;2(1). PMID: 25815208
     
  4. Taylor SM, Antonia AL, Harrington WE, Goheen MM, Mwapasa V, Chaluluka E, Fried M, Kabyemela E, Madanitsa M, Khairallah C, Kalilani-Phiri L, Tshefu A, Rogerson SJ, Ter Kuile FO, Duffy PE, Meshnick SR. Independent Lineages of Highly Sulfadoxine-Resistant Plasmodium falciparum Haplotypes, Eastern Africa. Emerg Infect Dis. 2014 Jul;20(7):1140-8. PMID: 24960247
     
  5. Book Chapter: Margolis E and Fredricks D. Bacterial Vaginosis. In: Sussman M. Molecular Medical Microbiology. Academic Press (UK), 2014.
     
  6. Poole N, Schwab J, Hageman J. A 9-Year-Old Male with Hypertension. Pediatr Ann. 2015 Jan;44(1): e10-3. PMID 25621628
     
  7. Roy SH, Tobin DV, Memar N, Beltz E, Holmen J, Clayton JE, Chiu DJ, Young LD, Green TH, Lubin I, Liu Y, Conradt B, Saito RM. A complex regulatory network coordinating cell cycles during caenorhabditis elegans development is revealed by a genome-wide RNAi screen. G3 (Bethesda). 2014, Feb; 4(5): 795-804. PMID: 24584095.
     
  8. Holmen JE, Lee B. A teenager with abdominal pain after completing treatment for endocarditis. Pediatr Infect Dis J. 2015 Jan;34(1):113; discussion 118-9. PMID:25741805
     
  9. Kristin N. Adams*, John D. Szumowski* and Lalita Ramakrishnan. (2014) Verapamil, and its metabolite noverapamil, inhibit macrophage-­‐induced, bacterial efflux-­‐mediated tolerance to multiple antitubercular drugs. J Infect Dis. 210(3):456-­‐66. PMCID: PMC4110457
     
  10. Harrington WE, Fried M, Duffy PE. Defending SP-IPTp: A Short Sighted Strategy. J Infect Dis. Correspondence. In press.

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

In addition to the NIH T32 training grant, other grants obtained to fund recent fellow projects include PIDS-St. Jude, Thrasher Foundation Award, PIDS Pediatric Scientist Development Program.

MAJOR FEATURES OF TRAINING PROGRAM:

The overall goal of this program is to train individuals for careers in academic pediatric ID who will be skilled investigators and clinical subspecialists. The usual fellowship training program consists of a three-year period; however modifications are possible depending on the background of the applicant.

Our program seeks to develop skilled investigators and clinicians through:

  • Training physicians in the basic scientific study of pediatric infectious disease
  • Developing outstanding clinical skills through a wide variety of clinical experiences
  • Providing mentorship for both scientific and clinical training
  • 2 years of dedicated research time

Research Training
We provide a strong research foundation upon which such a career can be based by providing a minimum of two years of research training related to an ongoing research project. Fellows are free to choose from the large number of outstanding research projects at Seattle Children's Hospital, the University of Washington, the Fred Hutchinson Cancer Research Institute, and the Seattle Biomedical Research Institute. Strong emphasis is placed on finding a research mentor who will foster the ultimate development of an independent research program.

Clinical Training
The subspecialty trainee will acquire clinical skills through didactic teaching, experience as a consultant in ID at a tertiary care hospital serving a broad geographic catchment area, and participation in conferences. Fellows emerge with extensive experience in management of a wide variety of infections, including bacterial, viral, fungal and parasitic infections in a wide variety of clinical settings including previously healthy children, as well as surgical and immunocompromised patients, including those with solid organ and bone marrow transplantation.

  • AFFILIATED HOSPITALS: Children's Hospital, approximately 320 pediatric beds, with additional training opportunities at Harborview Medical Center, the University of Washington Medical Center, and the Fred Hutchinson Cancer Research Center
  • NUMBER OF PEDIATRIC BEDS: 323
  • FELLOWS ACCEPTED EACH YEAR: 2 on average
  • TRAINING FOR: MD; DO; MD, PhD
  • FUNDING IS ENSURED FOR ALL 3 YEARS: YES
  • VISAS ACCEPTED: No, U.S. Residents only
  • IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? YES

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

  • Program provides training in diagnostic microbiology using laboratories on site:
    • Microbiology laboratory: YES
    • Clinical virus isolation laboratory: YES
    • Molecular diagnostics: YES
    • Including newer diagnostic methods such as MALDI-TOF
       
  • Program provides training in infection control and hospital epidemiology as:
    • Didactic lectures: YES
    • Hands on experience: YES
    • Infection Control Meetings/Membership: YES
       
  • Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:
    • Bacteriology/bacterial infections: YES
    • Epidemiology and statistics: YES
    • Infection control/hospital epidemiology: YES
    • Immunizations/Public health: YES
    • Mycology/fungal infections: YES
    • Parasitology/parasitic diseases: YES
    • Virology/viral diseases: YES
    • Antimicrobial agents: YES
       
  • Research opportunities in the section’s program could be described as:
    • Basic
    • Molecular
    • Epidemiologic
    • Clinical
    • International/Public Health
    • HIV, Basic
       
  • Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: Yes, with faculty at the University of Washington including adult ID and others
     
  • Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES
     
  • Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES
     
  • Program provides substantial clinical experiences for trainees in special areas/hosts:
    • Bone marrow transplantation
    • Solid organ/transplantation
    • Congenital immune deficiencies
    • Exposure to HIV infections in travelers/adoptees. Adults
       
  • Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES
     
  • Program has an NIH-sponsored training grant: YES
     
  • The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: YES

Average number of new outpatient consultations per month: 20

Average number of established outpatient follow-up visits per month: 40

Average number of new inpatient consultations per month: Approx. 60-90

Number of trainees completing program in the last 5 years: 11